Life history theory is often invoked to make universal predictions about phenotypic evolution. For example, it is conventional wisdom that organisms should evolve older ages at first reproduction if they have longer lifespans. We clarify that life history theory does not currently provide such universal predictions about phenotypic diversity. Using the classic Euler–Lotka model of adaptive life history evolution, we demonstrate how predictions about optimal age at first reproduction depend on rarely acknowledged, prior theoretical assumptions (i.e., axioms) about organismal development. (...) These developmental axioms include the rates, forms, and tradeoffs that relate to growth or differentiation. Developmental innovations transform the biology underlying these axioms. Consequently, Euler–Lotka and related life history models do not make coherent predictions at macroevolutionary scales, where developmental innovations occur (e.g., across mammals, birds, or insects). By focusing on historical innovations instead of universal rules, life history theory can reconnect with flourishing research in evolutionary developmental biology. (shrink)

Legal challenges to the FDA’s approval of mifepristone have destabilized patients’ ability to access controversial medicines like medication abortion. We argue that federal courts’ receptiveness to this litigation undermines the coherence and integrity of prescription drug regulation in the U.S.

Informed consent, decision-making styles and the role of patient-physician relationships are imperative aspects of clinical medicine worldwide. We present the case of a 74-year-old woman afflicted with advanced liver cancer whose attending physician, per request of the family, did not inform her of her true diagnosis. In our analysis, we explore the differences in informed-consent styles between patients who hold an "independent" and "interdependent" construal of the self and then highlight the possible implications maintained by this position in the context (...) of international clinical ethics. Finally, we discuss the need to reassess informed-consent styles suitable to the needs of each patient regardless of whether he or she resides in the United States or in Japan. (shrink)

This research note is meant to introduce into philosophical discussion the preliminary results of an empirical study on the state of blacks in philosophy, which is a joint effort of the American Philosophical Association’s Committee on the Status of Black Philosophers (APA CSBP) and the Society of Young Black Philosophers (SYBP). The study is intended to settle factual issues in furtherance of contributing to dialogues surrounding at least two philosophical questions: What, if anything, is the philosophical value of demographic diversity (...) in professional philosophy? And what is philosophy? The empirical goals of the study are (1) to identify and enumerate U.S. blacks in philosophy, (2) to determine the distribution of blacks in philosophy across career stages, (3) to determine correlates to the success of blacks in philosophy at different career stages, and (4) to compare and contrast results internally and externally to explain any career stage gaps and determine any other disparities. (shrink)

Viṣṇu is a central deity in the Hindu pantheon, especially in his manifestation as the seductive cattle-herding youth, Kṛṣṇa. The purāṇas are sacred texts, which, as the Sanskrit name implies, are collections of narratives from 'long ago'. The Viṣṇu Purāṇa is thus an ancient account of the universe and guide to life, which places Viṣṇu-Kṛṣṇa at the centre of creation, theology and reality itself. This text, composed about 1,500 years ago, provides a comprehensive and accessible introduction to the most important (...) themes and narratives that constitute the Hindu imagination: the creation and destruction of the universe, the origin of gods and mortals, the peopling of the world, and the structure and conduct of ideal brahminical society. The Viṣṇu Purāṇa describes the trials of exemplary devotees, the existential struggles between gods and demons, and the exploits of legendary cultural heroes. It also contains many ecstatic songs of praise for the deity. The ever-popular accounts of Kṛṣṇa's love games with the cattle-herding girls of Vṛṇdāvana, which have proliferated in literature, dance, song and visual arts over the millennia, are found here in authoritative form. This faithful yet fluent blank-verse rendering of this great Hindu classic is the first new English translation in over 100 years. It will be welcomed by the scholarly community, while remaining readily accessible to a general readership.--From the publisher's website. (shrink)

A large body of research has indicated international students in the United States and abroad experience difficulties understanding what academic integrity is and how to avoid academic misconduct, 159–172 2011; Brown & Howell, 2001; Gullifer and Tyson Studies in Higher Education, 39, 1202-1218 2014). While most studies focus on academic misconduct and academic corruption in research ethics, 339-358 2014), this study analyzes the length, English-language readability, and translation of academic integrity policies of 453 four-year U.S. institutions of higher education. Findings (...) indicate average academic integrity policies are over 2000 words long, are written above the 16th-grade reading level, and are very rarely translated into a language other than English. In addition, no institutions published their academic integrity policies in full on their institutional international student website, possibly rendering the policy difficult to locate on the institution’s website for international students. Implications for research, policy, and practice are addressed. (shrink)

In this article, I will be focusing specifically on cryopreservation and two of the American biotechnomedical tenets introduced by Robbie Davis-Floyd and Gloria St. John in their technocratic model of medicine: the “body as machine” and “death as defeat.” These axioms are embraced by both the biotechnomedical establishment as well as the cryopreservation communities when they discuss the future of humankind. In particular, I will be focusing on the political economy of cryopreservation as an embodiment of American neoliberalism—as well as (...) a Durkheimian death ritual—in the twenty-first century. Finally, I will theorize on a future populated by human beings from “the past” and the implications and consequences that may be caused by contemporary humans experiencing a temporal shift from traveling in deep time vis-à-vis cryopreservation. (shrink)

How diverse is philosophy? In this paper we explore recent data on the racial, ethnic, and gender diversity of philosophy students and faculty in the United States. We have found that women are underrepresented in philosophy at all levels from first-year intention to major through senior faculty. The past four years have seen an increase in the percentage of women philosophy majors at the undergraduate level, but it remains to be seen if this recent increase in the percentage of women (...) will eventually also show at more advanced stages. Temporal trends since 2000 also show substantial increases in the racial and ethnic diversity of philosophy majors at all levels of education from first-year undergraduate through PhD, with substantial declines in the percentage of non-Hispanic White philosophy majors and substantial increases in all other commonly measured racial/ethnic groups except for Native American / Alaska Native. Despite generally increasing diversity, people who identify as Hispanic (any race), or non-Hispanic Native American, Alaska Native, or Black remain substantially underrepresented in philosophy at all levels compared to their presence in the U.S. population, and in some cases also as compared to other majors. (shrink)

Techniques for resolving some types of inherited mitochondrial diseases have recently been the subject of scientific research, ethical scrutiny, media coverage and regulatory initiatives in the UK. Building on research using eggs from a variety of providers, scientists hope to eradicate maternally transmitted mutations in mitochondrial DNA by transferring the nuclear DNA of a fertilised egg, created by an intending mother at risk of transmitting mitochondrial disease, and her male partner, into an enucleated egg provided by another woman. In this (...) article we examine how egg providers for mitochondrial research and therapy have been represented in stakeholder debates. A systematic review of key documents and parliamentary debates shows that the balance of consideration tilts heavily towards therapeutic egg providers; research egg providers have been ignored and rendered invisible. However, mapping the various designations of therapeutic egg providers shows that their role is so heavily camouflaged that they have only an absent presence in discussions. We explore this puzzling ambivalence towards egg providers whose contributions are necessary to the success of current mitochondrial research and proposed therapies. We suggest that labels that diminish the contributions of egg providers serve certain governance objectives in managing possible future claims about, and by, therapeutic egg providers. We demonstrate that the social positioning of research egg providers is entangled within that of therapeutic egg providers which means that the former can also never receive their due recognition. This article contributes to the wider literature on the governance of new technological interventions. (shrink)

Key ethical issues arise in association with the conduct of stem cell research by research institutions in the United States. These ethical issues, summarized in detail, receive no adequate translation into federal laws or regulations, also described in this article. U.S. Federal policy takes a passive approach to these ethical issues, translating them simply into limitations on taxpayer funding, and foregoes scientific and ethical leadership while protecting intellectual property interests through a laissez faire approach to stem cell patents and licenses. (...) Those patents and licenses, far from being scientifically and ethically neutral in effect, virtually prohibit commercially sponsored research that could otherwise be a realistic alternative to the federal funding gap. The lack of federal funding and related data-sharing principles, combined with the effect of U.S. patent policy, the lack of key agency guidance, and the proliferation of divergent state laws arising from the lack of Federal leadership, significantly impede ethical stem cell research in the United States, without coherently supporting any consensus ethical vision. Research institutions must themselves implement steps, described in the article, to integrate addressing ethical review with the many legal compliance issues U.S. federal and state laws create. (shrink)

Writing a college-application essay has become a rite of passage for high-school seniors in the U.S., one whose importance has expanded over time due to an increasingly competitive admissions process. Various commentators have noted the disturbing evolution of these essays over the years, with an ever-greater emphasis placed on obstacles overcome and traumas survived. How have we gotten to the point where college-application essays are all too frequently competitive-victimhood displays? Colleges have an understandable interest in the disadvantages their applicants may (...) have suffered, but this interest—and the awareness of it among both applicants and their advisors—has led to a “race to the bottom”: in order to thrive (or even survive) in a particular competitive context, participants are forced to continuously lower relevant standards in a game of one-upmanship. With college essays, the competition is among high-school seniors for admission, the one-upmanship is an ever-escalating effort to persuade admission committees of one’s greater disadvantage, and the relevant standards being lowered are honesty, privacy, and dignity—or so I shall argue. As we shall see, this particular race to the bottom imposes unequal costs on certain groups and has implications stretching well beyond collegiate admissions. (shrink)

ABSTRACT:Although prior work has shown that employees with ethical leaders are less likely to engage in deviant or unethical behaviors, it is unknown whetherallemployees respond this way or to the same extent. Drawing on social learning theory as a conceptual framework, this study develops and tests hypotheses suggesting that two follower characteristics—conscientiousness and core self-evaluation—moderate the negative relationship between ethical leadership and workplace incivility. Data from employees of a U.S. public school district supported our predictions. Implications and future research directions (...) are discussed. (shrink)

This study examines the impact of board of director gender diversity on corporate tax aggressiveness. Based on a sample of 418 U.S. firms covering the 2006–2009 period, our ordinary least squares regression results show a negative and statistically significant association between female representation on the board and tax aggressiveness after controlling for endogeneity. Our results are consistent across several measures of tax aggressiveness and additional robustness checks.

Ranking systems such as The Times Higher Education’s World University Rankings and Shanghai Jiao Tong University’s Academic Rankings of World Universities simultaneously mark global status and stimulate global academic competition. As international ranking systems have become more prominent, researchers have begun to examine whether global rankings are creating increased inequality within and between universities. Using a panel Tobit regression analysis, this study assesses the extent to which markers of inter-institutional stratification and organizational segmentation predict global status among US research universities (...) as measured by position in ARWU. Findings indicate some support that both inter-institutional stratification and organizational segmentation predict global status. (shrink)

A major challenge in neuroscience is to understand what happens to a brain as it ages. Such insights could make it possible to distinguish between individuals who will undergo typical aging and those at risk for neurodegenerative disease. Over the last quarter century, thousands of human brain imaging studies have probed the neural basis of age-related cognitive decline. “Aging” studies generally enroll adults over the age of 65, a historical precedent rooted in the average retirement age of U.S. wage-earners. A (...) consequence of this research tradition is that it overlooks one of the most significant neuroendocrine changes in a woman’s life: the transition to menopause. The menopausal transition is marked by an overall decline in ovarian sex steroid production – up to 90% in the case of estradiol – a dramatic endocrine change that impacts multiple biological systems, including the brain. Despite sex differences in the risk for dementia, the influence that biological sex and sex hormones have on the aging brain is historically understudied, leaving a critical gap in our understanding of the aging process. In this Perspective, we highlight the influence that endocrine factors have on the aging brain. We devote particular attention to the neural and cognitive changes that unfold in the middle decade of life, as a function of reproductive aging. Next, we consider emerging evidence from animal and human studies that other endocrine factors occurring earlier in life (e.g. pregnancy, hormonal birth control use) also shape the aging process. Applying a women’s health lens to. (shrink)

Drawing on interviews and observational work with practicing U.K. plant scientists, this article uses Michel Callon's work as a tool to explore the issue of collaboration between academic science and business, in particular, calls by the Biotechnology and Biological Sciences Research Council for a return to “public good” plant science. In an article titled “Is Science a Public Good?” Callon contributed to the debate about the commercialization of science by suggesting that commercialization and the public good need not be incompatible. (...) Moving away from arguments that center on the effects of business involvement in science, he suggested that analysts use another model, centered on “diversity.” This model allows us to ask what society might want from science, what public good science might look like, and how public good science can be ensured while also recognizing that science cannot be easily separated from the market. (shrink)

When invited to describe what the experience of illness taught them, a select group of bioethicists took eagerly to the task. This commentary culls three themes from their reflections: responsiveness to vulnerability, love as the proper motive for care, and reflective practice. U.S. bioethics was slow to appreciate the importance of recognizing and responding to human vulnerability. These essays describe its central importance for those suffering illness and make educating a more empathic and responsive generation of caregivers a priority. Descriptions (...) of how family and friendship bonds with an ill person created a unique sense of their inherent dignity and needs clearly raises the question of whether or not love is a necessary motive for professional caregivers. Will our professional care always fall short if not motivated by genuine human love? Finally, each essay teaches anew the importance of the life lessons human experience can teach if we value reflection and seek to experience, understand and learn from our experience. (shrink)

Suppose that a school restricts student expression critical of homosexual conduct yet allows or actively supports student expression that promotes acceptance and tolerance of gays and lesbians. Can such a policy be justified if the anti-gay speech disrupts the educational environment of the school while the pro-gay speech does not? Or does the differential treatment of anti-gay and pro-gay speech constitute unconstitutional viewpoint discrimination because it distorts the marketplace of ideas within the school? Can viewpoint discrimination ever be justified on (...) the ground that anti-gay speech invades the rights of others under Tinker v. Des Moines Independent Community School District, 393 U.S. 503 (1969)? These were among the questions debated by Judges Reinhardt and Kozinski in the Ninth Circuit's now-vacated panel opinion in Harper v. Poway Unified School District, 445 F.3d 1166 (9th Cir. 2006), but their significance to the law of student speech is quite general. Courts are increasingly becoming concerned with the question of whether Tinker allows viewpoint-based restrictions of student speech, but so far jurists have not reached agreement on this question or even on the simpler question of what counts as viewpoint discrimination. This article attempts to clarify the emerging debate about the permissibility of viewpoint discrimination under Tinker and proposes modifications to the Tinker framework that would enable courts to deal more fruitfully with charges that school officials have imposed viewpoint-based restrictions on student speech. I argue that we should think of viewpoint discrimination as purposeful restriction of expression on the basis of governmental disagreement with the message. Tinker must be understood to bar purposeful viewpoint discrimination, but the conclusion that a school speech restriction constitutes purposeful viewpoint discrimination will come at the end rather than at the beginning of constitutional analysis. A school will never announce that it has restricted student speech on the basis of disagreement with the message; instead, it will claim that it has regulated speech to prevent harm. And this is something that schools (and the state more generally) may sometimes do - at least with sufficient justification. Tinker obviously contemplates the regulation of speech where necessary to prevent two specific sorts of harms - disruption to the school's mission and violations of the rights of other students - and so must require courts to distinguish between school speech restrictions based on impermissible ideological purposes and those based on the permissible purposes of preventing disruptions or violations of student rights. Tinker's substantial disruption test, I contend, should primarily be understood as a mechanism for helping courts to smoke out these impermissible purposes. (shrink)

Prudence has long been an important topic for rhetorical theorists and its place in intellectual history is becoming increasingly well documented. This essay develops a conception of prudence as an ideological construct, a term crafted in the history of its public usages to govern the relationship between common sense and political action as enacted in the name of historically situated social actors. From this perspective, prudence represents the recursive interaction between a rhetoric of judgment and the grounds on which that (...) rhetoric is evaluated by a historically particular community of arguers. A case study of the 1991 U.S. Senate debate regarding the authorization of offensive military action in the Persian Gulf illustrates how competing standards of prudential judgment are crafted and evaluated in discursive controversy. (shrink)

The United Nations Convention on the Rights of Persons with Disabilities, adopted on December 13, 2006, and entered into force on May 3, 2008, constitutes a key landmark in the emerging field of global health law and a critical milestone in the development of international law on the rights of persons with disabilities. At the time of its adoption, the U.N. High Commissioner for Human Rights heralded the CRPD as a rejection of the understanding of persons with disabilities “as objects (...) of charity, medical treatment and social protection” and an embrace of disabled people as “subjects of rights.”The text of the Convention itself, and the highly participatory process by which it was negotiated, signal a definitive break from previous international approaches that focused on disability within a medical model framework. In contrast to traditional approaches, the CRPD embraces a social model of disability, concentrating the disability experience not in individual deficiency, but in the socially constructed environment and the barriers that impede the participation of persons with disabilities in society. (shrink)

McDonough Hall, Room 508, 600 New Jersey Ave, NW, Washington, DC 20001, USA; Email: gostin{at}law.georgetown.edu ' + u + '@' + d + ' '//--> Abstract As a consequence of rapid globalization, the need for a coherent system of global health law and governance has never been greater. This article explores the health hazards posed by contemporary globalization on human health and the consequent urgent need for global health law to facilitate effective multilateral cooperation in advancing the health of populations (...) equitably. It sets forth the first definition of the emerging field of "global health law." After explicating the central features identified in the definition, the article examines the "grand challenges" to reaching the full potential of global health law to advance human health in just and effective ways. CiteULike Connotea Del.icio.us What's this? (shrink)

ABSTRACT The little-studied presidency of Benjamin Harrison offers valuable insights into the surprising role that political ideas can play in government. Harrison was a highly qualified president who demonstrated energetic leadership and political skill, but whose ideological commitment to the Republican party as a quasi-sacred enterprise overrode other important considerations, thereby contributing to one of the greatest economic catastrophes in U.S. history: the Depression of 1893-1897. His ideas about the Republican party were forged in its early years, when it led (...) the political battle against slavery; but when Harrison became president, the party’s interests in trade protectionism, veterans’ pensions, and silver drove him to support policies that eventually sent the economy into a tailspin from which it took years to recover. (shrink)

Religious conservatives in the U.S. have frequently opposed public-health measures designed to combat STDs among minors, such as sex education, condom distribution, and HPV vaccination. Using Rawls’s method of conjecture, I will clear up what I take to be a misunderstanding on the part of religious conservatives: even if we grant their premises regarding the nature and source of sexual norms, the wide-ranging authority of parents to enforce these norms against their minor children, and the potential sexual-disinhibition effects of the (...) above public-health measures, their opposition to at least one of these measures, HPV vaccination, cannot be justified. In fact, their comprehensive doctrines, when properly interpreted, should lead them to back this measure and thereby draw closer to a policy consensus with other citizens regarding teenage sexual health. (shrink)

Purpose. The paper is aimed to explicate a recently emerging anthropological model of homo eudaimonicus from its secular framework perspective. Theoretical basis. Secularity is considered in three aspects with reference to Taylor’s and Habermas’ ideas: as a common public sphere, as a phenomenological experience of living in a Secular Age, and as a background for happiness to become a major common value among other secular values in the Age of Authenticity. The modifications of happiness interpretation are traced from Early (...) Modernity till nowadays. The preconditions of the contemporary appeal to Aristotle’s eudaimonic theory of happiness are elucidated. The main characteristics of homo economicus anthropological model and reasons for its collapse in the contemporary world are analyzed. Specificities of the contemporary interpretations of eudaimonia are described with reference to the works of MacIntyre, Haybron, Hamilton, Kekes, Melnick, and others. A moral foundation and a behavioral strategy of homo eudaimonicus model are expounded and the role of this model in the life of a contemporary individual person and society is revealed. Originality. For the first time in the Ukrainian philosophical discourse, it is shown how secular ethics enables the rise of a new homo eudaimonicus model within a sphere of secularity; and it is argued that homo eudaimonicus is the result of overcoming the values crisis. It is revealed how homo eudaimonicus along with being descriptive becomes also a normative model of a new effective behavior strategy of a contemporary person facing the current social, economic, political, and environmental challenges. Conclusions. According to the contemporary interpretation, happiness as eudaimonia is a combination of the good life and the meaningful life; it is a human flourishing in this world through the accomplishment of a person’s life plan in the sphere of secularity. Homo eudaimonicus manifests the overcoming of values crisis and the rediscovery of purpose and meaning, this time on the secular basis. Homo eudaimonicus implies the realization of a person’s project of a happy and fulfilling life through moral behavior and socially useful activities. (shrink)

In this paper, I argue that perdurantism is incompatible with priority monism: the view that the universal mereological fusion, U, is fundamental. For the monist’s fundamental object can neither persist by being a trans-temporal object (i.e., a space-time ‘worm’) nor by being an instantaneous stage. If U persisted via being a worm, it would be grounded in its temporal parts, meaning that it would not be fundamental as it would not be ungrounded. If U were a stage, on the other (...) hand, it would face a problem from the possibility of ‘temporal gunk’. But if U persisted by neither being a worm nor a stage, then U could not persist via having temporal parts, and thus perdurantism would be false. Given that a similar combination of perdurantism and priority pluralism also faces a problem from temporal gunk, I conclude that perdurantism does not sit well with mereological based accounts of fundamentality. (shrink)

The United Nations ‘Protect, Respect and Remedy’ Framework,developed by the U.N. Special Representative JohnRuggie, brings together social expectations and law into anemerging policy framework of direct relevance to corporate social responsibility, CSR. The principle source of the Framework’s significance for the policy and practice of CSR is its definition of the theory of business responsibility for human rights as arising from business activities and relationships, and its deployment of due diligence for human rights risk as the core operational concept of (...) this theory of responsibility. The article considers the responsibility to respect human rights in light of theories about polycentric regulatory regimes and draws the conclusion that the Ruggie Framework creates a regulator dynamic in which both voluntarism and law have relevant and reinforcing roles to play in governing business behavior. In the wake of the adaptation of the Framework by the UN, the challenge for the field of CSR will be to adapt to an emerging reality in which business responsibility for ‘the social’ is increasingly a question of compliance and beyond. (shrink)

This research examines the impact of COVID-19 on food security in New York state and the innovative approaches employed by food assistance organizations to help address the changing and increasing demand for their services from March 2020 to May 2021. We examine the case study of New York’s Capital District region through a qualitative approach. We find that there was a sharp increase in utilization of emergency services during spring of 2020, which tapered off in the summer and fall of (...) 2020 but remained above the levels of need seen the previous year. Food assistance organizations quickly adapted to the increased demand for their services and changing conditions to reduce gaps in local food distribution chains: They reorganized and tapped into new sources for volunteers, networked with public and private organizations, and coordinated work with other regional food pantries for maximum impact. The flexibility of food assistance organizations to address the disruptions brought about by the COVID-19 pandemic highlights their critical roles in the U.S. food security environment. While organizations are aware of their shortcomings, constraints, and overall role in the American food system, the majority also expressed that the pandemic presented an opportunity to treat a complex problem together and to enact change. Several stakeholders also shared their hope that strengthening their networks and innovations may facilitate post-pandemic recovery, bring about systemic changes to address root causes of food insecurity, and better serve the communities most vulnerable to hunger and service disruptions. (shrink)

The U.S. National Institute of Allergies and Infectious Diseases and the National Institute of Mental Health have a new research priority: inclusion of terminally ill persons living with HIV in HIV cure-related research. For example, the Last Gift is a clinical research study at the University of California San Diego for PLWHIV who have a terminal illness, with a prognosis of less than 6 months. As end-of-life HIV cure research is relatively new, the scientific community has a timely opportunity to (...) examine the related ethical challenges. Following an extensive review of the EOL and HIV cure research ethics literature, combined with deliberation from various stakeholders and our experience with the Last Gift study to date, we outline considerations to ensure that such research with terminally ill PLWHIV remains ethical, focusing on five topics: 1) protecting autonomy through informed consent, 2) avoiding exploitation and fostering altruism, 3) maintaining a favorable benefits/risks balance, 4) safeguarding against vulnerability through patient-participant centeredness, and 5) ensuring the acceptance of next-of-kin/loved ones and community stakeholders. EOL HIV cure-related research can be performed ethically and effectively by anticipating key issues that may arise. While not unique to the fields of EOL or HIV cure-related research, the considerations highlighted can help us support a new research approach. We must honor the lives of PLWHIV whose involvement in research can provide the knowledge needed to achieve the dream of making HIV infection curable. (shrink)

David Dranove and Lawton Burn’s new collaboration Big Med: Megaproviders and the High Cost of Health Care in America provides readers with a comprehensive tutorial on consolidation in United States healthcare markets over the past 40 years. Although the book is most explicitly aimed at those who look around and wonder how we arrived at a healthcare landscape dominated by giants, anyone with a serious interest in the prices of U.S. healthcare will want to have this rigorous and timely treatment (...) on their bookshelf. (shrink)

Participants in clinical research sometimes view participation as therapy or exaggerate potential benefits, especially in phase I or phase II trials. We conducted this study to discover what methods might improve cancer patients’ understanding of early-phase clinical trials. We randomly assigned 130 cancer patients from three U.S. medical centers who were considering enrollment in a phase I or phase II cancer trial to receive either a multimedia intervention or a National Cancer Institute pamphlet explaining the trial and its purpose. Intervention (...) participants were 32 times more likely to believe that the trial’s purpose was to examine safety and 60 % less likely to believe they would experience long-term benefit or cure. There was no difference in enrollment decision. However, while patients’ understanding of the trial’s purpose improved and expectations of long-term benefit diminished, half the respondents still believed they would experience long-term benefit or cure from participation. Therefore, we conclude that multimedia interventions such as this one may help oncologists to explain the risks and benefits of early-phase cancer trials in a way that patients can more easily understand, helping them to make more informed decisions about participation. But further research into other factors that influence patients’ beliefs about the outcome of enrollment is needed, both to modify the interventions and to determine how malleable patient beliefs are. (shrink)

In the last five years, a number of U.S. companies have either moved their locus of incorporation to countries with more favorable tax laws, or announced such moves. Given this trend toward “inversions”, and the polemics that have accompanied it, we offer two ways in which the ethics of such a move can be evaluated. We provide multinational executives with two applications of ethics to inversion: Kant’s deontological theory and the consequentialist perspective of utilitarianism.

Background: Facial proportionality and symmetry are positively associated with perceived levels of facial attractiveness. -/- Objective: The aims of this study were to confirm and extend the association of proportionality with perceived levels of attractiveness and character traits and determine differences in attractiveness and character ratings between "anomalous" and "typical" faces using a large dataset. -/- Methods: Ratings of 597 unique individuals from the Chicago Face Database were used. A formula was developed as a proxy of relative horizontal proportionality, where (...) a proportionality score of "0" indicated perfect proportionality and more negative scores indicated less proportionality. Faces were categorized as "anomalous" or "typical" by 2 independent reviewers based on physical features. -/- Results: Across the ratings for all faces, Spearman correlations revealed greater proportionality was associated with attractiveness ( ρ = 0.292, P < 0.001) and trustworthiness ( ρ = 0.193, P < 0.001), while lesser proportionality was associated with impressions of anger (ρ = 0.132, P = 0.001), dominance (ρ = 0.259, P < 0.001), and threateningness ( ρ = 0.234, P < 0.001). Mann-Whitney U tests revealed the typical cohort had significantly higher levels of proportionality (-13.98 versus -15.14, P = 0.030) and ratings of attractiveness (3.39 versus 2.99, P < 0.001) and trustworthiness (3.48 versus 3.35, P < 0.001). -/- Conclusions: This study demonstrated that facial proportionality is not only significantly associated with higher ratings of attractiveness, but also associated with judgements of trustworthiness. Proportionality plays a role in evoking negative attributions of personality characteristics to people with facial anomalies. (shrink)

_Purpose._ The article aims, through a comparison of the modern identity as presented in Charles Taylor’s concept with the Postmodern era identities, to show the strengths and weaknesses of Charles Taylor’s position on preserving or prolonging the Modern era identity to our time, as well as to define the specifics of _liquid modernity_ compared to the New Age. _Theoretical basis._ Given the relevance of the topic of the human search for authentic existence in the modern world, the author (...) analyzes Taylor’s belief that the moral ideal of authentic identity emerged in the New Age. This ideal to contrast the idea of it in the previous periods is not set from the outside but is formed or created by a human himself. In addition, it is so powerful and productive that it must be fought for nowadays. After Taylor, since the existence of modern people tends to experience negative distortions associated with the focus on consumer individualism, instrumental thinking, and their loss of political freedom, the only possible way out is to turn to the ideal of authenticity of modern times. However, the article emphasizes that the modern studies of the Second Modernity (U. Beck) or liquid modernity (Z. Bauman) show a rather radical change in social reality, which, accordingly, requires new types of identity. _Originality._ The article argues that the identity formed in the New Age had signs of authenticity only owing to the socio-economic system of the time that formed a human as a self-acting being who determines his or her destiny. This person was characterized by such traits as individualism, self-sufficiency, self-reliance, victory, heroism, and so on. However, the article emphasizes that today the situation has changed radically, as the reality of the Postmodern era is characterized by the fact that instead of stable, clearly defined life forms and institutions we are dealing with changing, fluid, "liquid" (Z. Bauman) institutions and behaviours of people. Diversity, uncertainty, and pluralism are the hallmarks of this era that need to be taken into account in one way or another. Therefore, although Taylor’s arguments for defending the modern identity are logically invulnerable, they have the disadvantage of not taking into account the irreversibility of the changes that have taken place in modern reality. Therefore, the ideal of authenticity formed in the New Age may not be adequate in the times of pluralism and the development of other dimensions of identity. _Conclusions._ Taylor’s interpretation of modern authenticity was based on the idea of man as one who constantly constructs himself and is focused on the future, which we can imagine, plan and make some effort to achieve. This position of Taylor is criticized in the article. I substantiate the view that both the moral ideal and its components can change in the process of historical development. This becomes clear if we take into account the gap that manifested itself in the shift of value orientations during the transition from the Modern to the Postmodern era. Nowadays, we have a process of changing the basic conditions that determined the identity of a modern human, and the formation of new _basic conditions_ that are suggested as requiring identity redefinition in a post-industrial network society. (shrink)

Turing progressions have been often used to measure the proof-theoretic strength of mathematical theories: iterate adding consistency of some weak base theory until you “hit” the target theory. Turing progressions based on n-consistency give rise to a \ proof-theoretic ordinal \ also denoted \. As such, to each theory U we can assign the sequence of corresponding \ ordinals \. We call this sequence a Turing-Taylor expansion or spectrum of a theory. In this paper, we relate Turing-Taylor expansions (...) of sub-theories of Peano Arithmetic to Ignatiev’s universal model for the closed fragment of the polymodal provability logic \. In particular, we observe that each point in the Ignatiev model can be seen as Turing-Taylor expansions of formal mathematical theories. Moreover, each sub-theory of Peano Arithmetic that allows for a Turing-Taylor expansion will define a unique point in Ignatiev’s model. (shrink)

In the consolidated cases Altitude Express v. Zarda, Bostock v. Clayton County, and R.G. & G.R. Harris Funeral Homes v. EEOC, the Supreme Court will decide whether or not Title VII prohibits discrimination on the basis of sexual orientation or gender identity. Although the parties disagree as to the appropriate formulation of a but-for test to determine whether or not there was a discriminatory outcome, all parties do agree to the use of such a test, which asks “whether the evidence (...) shows ‘treatment of a person in a manner which but for that person’s sex would be different.’” City of Los Angeles, Dep’t. of Water and Power v. Manhart, 435 U.S. 702, 711 (1978). However, but-for tests confuse more than they clarify the inquiry; a discriminatory outcome cannot be explained by appeal to just a discrete characteristic of a particular person. Individuals are not discriminated against because of these characteristics per se. Rather, they are discriminated against because of the social meanings and expectations that attach to these characteristics. Beyoncé and Taylor Swift illustrate the difference between individual-level causation and social explanation in two separate songs, “If I Were a Boy” and “The Man.” The explanation for why the counterfactual ‘male’ Beyoncé and Swift are evaluated differently than their current ‘female’ versions does not lie in individual-level features considered apart from the social world, but in social-level roles and expectations associated with those features. For this reason, a social explanation test—one that asks whether the social meanings of sex characteristics, rather than the characteristics per se, explain the outcome in question—is more suitable for determining whether or not Title VII has been violated. (shrink)

Proboj zapadne europske filozofske misli na čijem se začelju pojavljuje ime francuskog mislioca R. Descartesa za sobom je donijelo oživljavanje čovjekove svijesti – tzv. post-renesansno intelektualno buđenje koje je navijestilo i označilo početak novog – modernoga doba, koje je na spoznajnoteorijskoj razini prepoznato kao početak vladavine instrumentalnog uma, odnosno, hegemonije Descartesovog cogita.U ovome radu nastoji se istražiti, pojasniti i protumačiti ulogu i značaj cogita u odnosu na moralno djelovanje modernoga čovjeka u percepciji suvremenog i glasovitog kanadskog filozofa, teoretičara i mislioca (...) Charlesa Taylora. Ima li um doista ekskluzivni primat nad čovjekovim djelovanjem, te kako u svjetlu uma objasniti i razumjeti krizu ethosa suvremenog čovjeka i pokušati pronaći adekvatno rješenje za pitanje globalne krize morala koja je zahvatila kompletnu civilizaciju našeg doba? – samo su neka među sličnim pitanjima koja će se propitati u ovome radu.The breakthrough of the Western European philosophic thought, whose final name is that of the French theorist R. Descartes, brought with it the revival of man’s conscience or the so-called post-Renaissance intellectual awakening, which announced and signified the beginning of a new – modern age, that was recognized on the cognitive-theoretical level as the beginning of the rule of instrumental reason, that is, the hegemony of the Descartean cogito.This presentation tends to research, clarify and interpret the role and the significance of the cogito in relationship with man’s moral action and generally, with the theory of morality of the modern Canadian philosopher, theorist and thinker Charles Taylor. Does reason indeed hold exclusive supremacy over man’s actions and how does one explain and understand the crisis of the modern man’s ethos in the light of reason, and try to find an adequate solution for the issue of a global morality crisis, which has taken over the entire civilization of our time? – are only some among a number of similar questions that will be discussed in this paper. (shrink)

El propósito de este artículo es fortalecer los vínculos entre las razones de justicia y las razones históricas para justificar el reconocimiento de ciertos derechos en favor de grupos culturalmente diferenciados. Intento con ello mostrar que a la lucha por la defensa de la preservación de ciertas culturas no es marginal, sino más bien esencial, el hecho de que dicha defensa provenga de una historia de exclusión. Acudiendo a ejemplos, en la primera parte del trabajo intentaré integrar algunos rasgos de (...) lo que Charles Taylor entiende por proceso de formación de la identidad al conjunto de etapas que, según Luis Villoro, dan lugar a la proyección de un modelo de justicia. En la segunda parte contaré algunos episodios del reciente proceso de recuperación territorial de la comunidad indígena U'wa en Colombia. El propósito de esta parte del trabajo es fortalecer el vínculo que establece Villoro entre las historias de exclusión y los procesos de consolidación de la justicia. A modo de conclusión y teniendo en cuenta la diferencia planteada por Ernst Tugendhat entre derechos generales y derechos especiales, mostraré en qué medida las historias tristes no dejan de constituirse en contenidos para la justicia una vez que la ley positiva ha consagrado una serie de derechos. (shrink)

In this response, I suggest that Black southern women in the U.S. have always been central to the “reconstruction” that Taylor identifies as a central theme of Black aesthetics. Building on his allusions to Alice Walker and Jean Toomer, I explore Walker’s tearful response (in In Search of Our Mothers’ Gardens: Womanist Prose (1983) to Toomer’s Cane (2011). Walker identifies their mothers’ and grandmothers’ informal arts of storytelling and gardening as the hidden roots of both her and Toomer’s work. (...) I suggest that Walker’s tears function to water her mother’s (and othermothers’) gardens, thereby sustaining southern Black women’s foundational work in reconstruction. Through telling their stories and planting gardens, along with crafting meals, designing clothes, and designing and decorating homes, southern Black women have always been necessary to Black aesthetics—filling worlds with aesthetically-rich and energetic artworks that Black formal artists such as Walker channel and transfigure into their formal artistic productions. (shrink)

PLATO: PROTAGORAS, trans, with Notes by C. C. W. Taylor. Clarendon Press: O.U.P., 1976. vii+230 pp. £7.50 cloth, £3.75 paper.

Peer review is often taken to be the main form of quality control on academic research. Usually journals carry this out. However, parts of maths and physics appear to have a parallel, crowd-sourced model of peer review, where papers are posted on the arXiv to be publicly discussed. In this paper we argue that crowd-sourced peer review is likely to do better than journal-solicited peer review at sorting papers by quality. Our argument rests on two key claims. First, crowd-sourced peer (...) review will lead on average to more reviewers per paper than journal-solicited peer review. Second, due to the wisdom of the crowds, more reviewers will tend to make better judgments than fewer. We make the second claim precise by looking at the Condorcet Jury Theorem as well as two related jury theorems developed specifically to apply to peer review. (shrink)

: This response to the preceding article by Gastmans, Dierckx de Casterle, and Schotsmans challenges the notion of "good care" as the ultimate goal of nursing practice, explores further the possible goals of nursing and how they may be identified, and presents six elements of professional caring along with their related virtues and moral obligations.